Poster Presentation RACI Biomolecular Division Conference 2013

Development of Pyrrolopyrimidines as Kinase Inhibitors (#94)

Veronica Tecchio 1 , Milena L Czyz 1 , Belinda C Huff 1 , Joana E Da Rocha 1 , Jonathan C Morris 1
  1. UNSW, Kensington, NSW, Australia

Variolin B is a marine alkaloid, which was isolated from the rare and difficult-to-access Antarctic sponge Kirkpatrickia varialosa.1 It has been found to be a potent kinase inhibitor.2 In order to discover new inhibitors with better selectivity and drug-like properties, the Morris Group have developed libraries of truncated analogs of Variolin B.

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Those compounds were found to be more selective for kinases that regulate alternative splicing. We are currently expanding these libraries by examining different aryl pendent rings and different amines.

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