Oral Presentation RACI Biomolecular Division Conference 2013

Synthesis of novel biologically active scaffolds based on flavones and isoflavones (#8)

Naresh Kumar 1
  1. The University of New South Wales, Sydney, NSW, Australia

Flavonoids are a particularly widely studied class of phytoestrogens that are found throughout the plant kingdom, and are known to possess diverse biological and pharmacological properties such as anti-oxidant, anti-viral and anti-cancer. Many flavonoids exist as dimers, comprising identical or non-identical units joined symmetrically or non-symmetrically through various linkages. Our group has exploited the carbocation reactivities of flavones and isoflavones to generate a wide range of novel flavonoids, such as the dependensin analogues 11,2 and alternate scaffold 23,4, which have been shown to possess a wide range of interesting biological activities. The results of these studies will be presented in this talk.

838-Blue%20Mountains%20conf.png

  1. Deodhar, M.; Black, D. StC.; Kumar, N. Tetrahedron, 2007, 63, 5227-5235.
  2. Devakaram, R., Black, D. StC., Andrews, K. T., Fisher, G. M., Davis, R. A., Bioorg. Med. Chem., 2011, 19, 5199-5206
  3. Devakaram R.; Black, D. StC.; Kumar, N. Tetrahedron Lett., 2010, 51, 3636-3638
  4. Devakaram, R., Black, D. StC., Choomuenwaib, V., Davis, R. A., Kumar, N., Bioorg. Med. Chem., 2012, 20, 1527-1534